付玉华

发布时间:2021-06-27浏览次数:4690

教师基本信息

职称:副研究员

电子邮箱:fuyuhua@fudan.edu.cn

办公地点:mg4355电子娱乐官网江湾校区生命科学院C221

 

个人简介:

男,博士,硕士生导师。20156月博士毕业于mg4355电子娱乐官网生物医学研究院,同年于mg4355电子娱乐官网脑科学研究院进行博士后训练(2015.7-2017.11),201712月起任mg4355电子娱乐官网生命科学院青年副研究员、副研究员。

 

研究方向:

自噬和脂自噬机制与应用;聚谷氨酰胺(polyQ)疾病和聚甘氨酸(polyG)疾病发生机制与干预。

 

学术兼职:神经科学学会会员,细胞生物学会会员等

 

科研项目:

主持国家自然科学基金面上项目1项(2019)和上海市科委项目2项(2022),作为骨干参与国家重点研发(2022)和国家重大研究计划集成项目(2020)及上海市科委重点项目(2020)。

 

获奖情况:

长三角神经科学青年科学家奖(2020);Sanofi-Cell Research年度杰出论文奖(2022

 

授课情况:功能解剖学与组织学(本科生),生物物理书报讨论(研究生),生理学前沿(研究生)

 

招生专业:神经科学、细胞生物学

 

代表性论文和论著:

1. Ningxie Chen; Boxun Lu*; Yuhua Fu* ; Autophagic Clearance of Lipid Droplets Alters Metabolic Phenotypes in a Genetic Obesity–Diabetes Mouse Model, Phenomics,2022 Nov 19;3(2):119-129.(封面论文,*Co-corresponding author)

2. Fu, Yuhua; Chen, Ningxie; Wang, Ziying; Luo, Shouqing; Ding, Yu; Lu, Boxun ; Degradation of lipid droplets by chimeric autophagy-tethering compounds, Cell Research, 2021, 31(9): 965-979(封面论文,Sanofi-Cell Research 2021年度杰出论文)

3. Xiaodan Zhang; Xue Wen; Ismael Al-Ramahi; Juan Botas; Boxun Lu;Yuhua Fu ; Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy, Neuroscience Bulletin, 2021, 38(1): 99-103.

3. Xiao-jing Li#; Yuan-yuan Zhang#;Yu-hua Fu#; Hao Zhang; He-xuan Li;Quan-fu Li; Hai-ling Li; Ren-ke Tan; Chen-xiao Jiang; Wei Jiang; Zeng-xia Li;Cheng Luo; Bo-xun Lu; Yong-jun Dang; Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex, Acta Pharmacologica Sinica, 2021, 42(1): 1-11. #co-first author

5. Yuhua Fu#; Peng Wu#; Yuyin Pan#; Xiaoli Sun#; Huiya Yang; Marian Difiglia; Boxun Lu; A toxic mutant huntingtin species is resistant to selective autophagy, Nature Chemical Biology, 2017, 13(11): 1152-1154. #co-first author

6. Meng Yu#; Yuhua Fu#; Yijiang Liang#; Haikun Song; Yao Yao; Peng Wu;Yuwei Yao; Yuyin Pan; Lixiang Ma; Saiyin Hexige; Yu Ding; Shouqing Luo; Boxun Lu; Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models, Cell Research, 2017, 27(12): 1441-1665.#co-first author