吴家雪

发布时间：2021-06-28浏览次数：4896

教师基本信息：

姓名：吴家雪

职称：研究员

电子邮箱：jiaxue@fudan.edu.cn

办公地点：mg4355娱乐线路检测官网 A507室

办公电话：021-31246554


研究方向

肿瘤发生发展和转移的机理研究。以肿瘤细胞、模式动物和临床样本为模型，研究DNA损伤修复，信号转导和翻译后修饰（磷酸化和腺苷二磷酸核糖化）等在肿瘤（肝癌、肺癌）发生发展和复发转移中的功能及分子机制，为肿瘤诊疗提供重要生物学标志物和分子靶标。


个人简介

2006年博士毕业于mg4355电子娱乐官网，随后赴美国密歇根大学从事博士后研究。2012年回国，任mg4355娱乐线路检测官网研究员，博士生导师。获得教育部自然科学二等奖（第3完成人，2020）和复星医药奖。主持或参与国家重大科技专项课题和重点研发项目，以及基金委面上项目。


授课情况

主讲本科生选修课程《分子肿瘤学和遗传学》


招生专业

遗传学/细胞生物学


代表性论文和论著

  1. Huan Feng#, Juan Liu, Yangyang Qiu, Yao Liu, Hexige Saiyin, Xiao Liang, Feng Zheng, Ying Wang, Deke Jiang, Ying Wang, Long Yu, Wei Su, Suqin Shen*, Jiaxue Wu*. RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression. Oncogene, 2020 Aug;39(33):5495-5506

  2. Yahui Zhao#; Xiaoding Hu; Li Wei; Dan Song; Juanjuan Wang; Lifang You; Hexige Saiyin; Zhaojie Li; Wenbo Yu; Long Yu; Jin Ding; Jiaxue Wu*.PARP10 suppresses tumor metastasis through regulation of Aurora A activity. Oncogene, 2018.5, 37(22): 2921~2935

  3. Changjuan Shao #; Yangyang Qiu; Juan Liu; Huan Feng; Suqin Shen; Hexige Saiyin; Wenbo Yu; Youheng Wei; Long Yu; Wei Su; Jiaxue Wu*. PARP12 (ARTD12) suppresses hepatocellular carcinoma metastasis through interacting with FHL2and regulating its stability. Cell Death and Disease, 2018.8.28, 9(9)

  4. Xiaoding Hu# ; Yahui Zhao; Li Wei; Bo Zhu; Dan Song; Juanjuan Wang;Long Yu; Jiaxue Wu *.CCDC178 promotes hepatocellular carcinoma metastasis through modulation of anoikis. Oncogene, 2017.07.13, 36(28): 4047~4059

  5. Hao Cai# ; Hexige Saiyin #; Xing Liu# ; Dingding Han# ; Guoqing Ji #;Bo Qin; Jie Zuo; Suqin Shen; Wenbo Yu; Jiaxue Wu* ; Yanhua Wu* ; Long Yu* .Nogo-B promotes tumor angiogenesis and provides a potential therapeutic target in hepatocellular carcinoma. Molecular Oncology, 2018.12, 12(12): 2042~2054

  6. Jiaxue Wu#; Yibin Chen; Lin-Yu Lu; Yipin Wu; Michelle T Paulsen; Mats Ljungman; David O Ferguson; Xiaochun Yu *.Chfr and RNF8 synergistically regulate ATM activation. Nature Structural & Molecular Biology, 2011.6.26, 18(7): 761~768

  7. Chao Liu# ; Jiaxue Wu# ; Sharad C. Paudyal; Zhongsheng You; Xiaochun Yu*.CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Research, 2013.2.1, 41(3): 1698~1710

  8. Feng Zhang# ; Jianglin Ma# ; Jiaxue Wu# ; Lin Ye; Hong Cai; Bing Xia*;Xiaochun Yu*.PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Current Biology, 2009.3.24, 19(6): 524~529

  9. Jiaxue Wu# ; Linyu Lu; Xiaochun Yu*. Role of BRCA1 in DNA damage response. Protein Cell, 2010.2.1, 1(2): 117~123  

  10. Jiaxue Wu#; Michael S. Y. Huen; Lin-Yu Lu; Lin Ye; Yali Dou; Mats Ljungman; Junjie Chen; Xiaochun Yu*. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Molecular and Cellular Biology, 2009.2.1, 29(3): 849~860