姓名：王永明(Yongming Wang)
职称：教授(Professor)
电子邮箱：yonmiwang@gmail.com
办公地点：mg4355电子娱乐官网江湾校区mg4355娱乐线路检测官网C623(the School of Life Sciences Building C623)
办公电话：021-31246624
研究方向：
基因编辑，基因治疗
Genome editing; Gene therapy
个人简介：
王永明博士，mg4355娱乐线路检测官网教授。2001年本科毕业于兰州大学；2004硕士毕业于东北师范大学，导师为刘宝教授。2005-2010年在德国马克思戴尔布吕克分子医学中心（MDC）师从Zsuzsanna Izsvak教授研究睡美人转座子，取得了柏林自由大学博士学位。2010-2013年在斯坦福大学师从Joseph Wu教授做博士后，用基因编辑技术和多能干细胞技术研究心肌病。
Dr. Wang Yongming is a distinguished professor at the School of Life Sciences, Fudan University. He earned his bachelor's degree in 2001 from Lanzhou University and completed his master's degree in 2004 at Northeast Normal University under the mentorship of Professor Liu Bao. From 2005 to 2010, he conducted extensive research on the Sleeping Beauty transposon at the Max-Delbruck Center for Molecular Medicine (MDC) in Germany, supervised by Professor Zsuzsanna Izsvak, and successfully obtained his doctoral degree from the Free University of Berlin.
During the period from 2010 to 2013, Dr. Wang served as a postdoctoral fellow at Stanford University under the guidance of Professor Joseph Wu. His research during this time focused on leveraging gene editing techniques and pluripotent stem cell methodologies to investigate cardiomyopathy. Currently, Dr. Wang is primarily involved in the advancement of novel CRISPR tools and conducting groundbreaking research in the field of gene therapy.
授课情况：
本科生生物科学研究设计与实践
研究生专业外语
Biological Science Research Design and Practice for undergraduate students;
Professional Foreign Language for graduate students.
招生专业：
遗传(Genetics)
科研项目：
主持4项国家自然科学基金委面上项目，参与3项科技部重大研发项目。
Dr. Wang Yongming was supported by three grants from the National Key Research and Development Program of China and four grants from the National Natural Science Foundation of China.
获奖情况：
2015年获得年国家青年人才项目
2020年获得中国技术市场协会金桥奖
2020年获得金龙鱼合成生物学学者奖
2022年获得国家高层次领军人才项目
Received the National Youth Talent Program in 2015
Received the Golden Bridge Award from the China Technology Market Association in 2020
Received the Golden Dragon Fish Synthetic Biology Scholar Award in 2020
Received the National High Level Leading Talent Program in 2022
代表性论文和论著：
1. Man Qi#, Shuhong Ma#, Jingtong Liu#, Xujie Liu, Jingjing Wei, Wen-Jing Lu, Siyao Zhang, Yun Chang, Yongshuai Zhang, Kejia Zhong, Yuting Yan, Min Zhu, Yabing Song, Yundai Chen, Guoliang Hao, Jianbing Wang, Li Wang, Andrew S Lee, Xiangbo Chen*, Yongming Wang*, Feng Lan*. In vivo base editing of Scn5a rescues type 3 long QT syndrome in mice. Circulation. 2023 Nov 15.
2. Chengdong Zhang#, Yuan Yang#, Tao Qi, Yuening Zhang, Linghui Hou, Jingjing Wei, Jingcheng Yang, Leming Shi, Sang-Ging Ong, Hongyan Wang, Hui Wang*, Bo Yu*, Yongming Wang*. Prediction of base editor off-targets by deep learning. Nature communications. 2023 Sep 2;14(1):5358.
3. Siqi Gao1#, Yao Wang1#, Tao Qi#, Jingjing Wei, Ziying Hu, Jingtong Liu, Shuna Sun*, Huihui Liu*, Yongming Wang*. Genome editing with natural and engineered CjCas9 orthologs. Molecular Therapy. 2023 Apr 5; 31(4): 1177-1187.
4.Yao Wang, Tao Qi, Jingtong Liu, Yuan Yang, Ziwen Wang, Ying Wang, Tianyi Wang, Miaomiao Li, Mingqing Li, Daru Lu, Alex Chia Yu Chang, Li Yang, Song Gao, Yongming Wang*, Feng Lan*. A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing. Science Advances. 2023 Feb 10;9(6):eabo6405.
5. Shuai Wang#, Chen Tao#, Huilin Mao, Linghui Hou, Yao Wang, Tao Qi, Yuan Yang, Sang-Ging Ong, Shijun Hu*, Renjie Chai*, Yongming Wang*. Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG PAM recognition. PLoS Biology. 2022 Nov 30;20(11): e3001897.
6. Jingjing Wei, Linghui Hou, Jingtong Liu, Ziwen Wang, Siqi Gao, Tao Qi, Song Gao, Shuna Sun*, Yongming Wang*. Closelyrelated type II-C Cas9 orthologs recognize diverse PAMs. eLife. 2022 Aug 12;11:e77825.
7. Shuai Wang, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi, Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu, Renjie Chai*, Yongming Wang*. Compact SchCas9 Recognizes the Simple NNGR PAM. Advanced Science. 2022 Feb;9(4):e2104789.
8. Shuhong Ma#, Wenjian Jiang#, Xujie Liu#, Wen-Jing Lu, Tao Qi, Jingjing Wei, Fujian Wu, Yun Chang, Siyao Zhang, Yabing Song, Rui Bai, Jianbing Wang, Andrew S. Lee, Hongjia Zhang*, Yongming Wang*, Feng Lan*. Efficient Correction of a Hypertrophic Cardiomyopathy Mutation by ABEmax-NG. Circulation Research. 2021 Oct 29;129(10):895-908.
9. Ziying Hu #, Chengdong Zhang#, Shuai Wang, Siqi Gao, Jingjing Wei, Miaomiao Li, Linghui Hou, Huilin Mao, Yanyan Wei, Tao Qi, Hongmao Liu, Dong Liu, Feng Lan, Daru Lu, Hongyan Wang*, Jixi Li*, Yongming Wang*. Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity. Nucleic Acids Research. 2021 Apr 19 ;49(7): 4008-4019.
10. Daqi Wang#, Chengdong Zhang#, Bei Wang, Bin Li, Qiang Wang, Dong Liu, Hongyan Wang, Yan Zhou, Leming Shi, Feng Lan*, Yongming Wang*. Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning. Nature Communications. 2019 Sep 19;10(1):4284.