周兆才

发布时间：2021-05-06浏览次数：10249

教师基本信息

姓名：周兆才

职称：教授

职务：院长助理

电子邮箱：zhouzhaocai@fudan.edu.cn

办公地点：mg4355娱乐线路检测官网A407室

办公电话：021-31246635

个人网页/课题组主页：http:/Data/View/3403


研究方向

肿瘤发生及免疫应答的分子细胞信号机制

本团队主要以胃肠道为研究体系，阐释组织器官生长与稳态维持的调控规律，揭示相关疾病的发生发展机制，发现诊疗标志物，提出创新性的诊疗策略，获得靶向药物原型。未来将持续聚焦消化道肿瘤特别是胃癌，重点探究：（1）不同亚型胃癌的细胞起源与异质化演变，从而为研发新型靶向药物提供理论基础；（2）胃癌相关免疫微环境重塑与演化，从而为研发新型肿瘤免疫治疗策略提供理论基础。为此，我们将进一步交叉整合结构生物学、细胞信号转导、小鼠模型、单细胞组学，以及类器官等技术体系，并着重发展以细胞-细胞互作为背景的遗传谱系示踪技术和以化学生物学为背景的多肽药物设计及靶向干预。


个人简介

2004年博士毕业于中国科学技术大学，随后赴美国宾州大学（UPenn）从事博士后研究。2009年引进回国，历任中科院上海生化与细胞所、分子生物学国家重点实验室、细胞生物学国家重点实验室研究员。2014年被授予中科院杰出青年科技创新人才称号。2017年任中科院分子细胞科学卓越创新中心特聘研究员，同年获国家自然科学基金委医学部“杰青”资助。2020年任mg4355电子娱乐官网特聘教授，遗传工程国家重点实验室研究组长。担任国家科技部 “发育和代谢：组织器官生长与尺寸控制” 重点专项首席科学家。主持国家自然科学基金委重点、重大、面上及上海市重点等基金项目，并获中科院战略性科技先导专项资助。曾任中科院与高校联合交叉创新团队负责人（GPCR信号转导）。担任Frontiers in Immunology等学术期刊编辑；《细胞生物学》、《生命的化学》等期刊编委；上海市生物工程学会理事、中国抗癌协会肿瘤胃肠病学专业委员会委员、中国细胞生物学会医学细胞生物学分会委员。研究成果：

长期关注组织器官间通讯与疾病，近年来研究胃肠道肿瘤发生及免疫应答，代表性工作聚焦Hippo等器官尺寸控制信号通路调控胃肠道肿瘤发生及免疫应答的机制与功能，发现了一批疾病诊断标志物和先导药物，在Cancer Cell (2)、Nature Immunology、Nature Communications、Advanced Science、Nano Letters、Journal of Experimental Medicine (2)、EMBO Journal (2)、Cell Research (2)、Proceedings of National Academy of Sciences、Cancer Research、Protein Cell等国际学术期刊发表研究论文70余篇，参与编写英文专著1部，申请发明专利10余项。成果被Cell、Nature Reviews Cancer、Cancer Cell、Nature China、Science Signaling、F1000Prime评价和推荐，多次应邀为Oncogene、Cellular Molecular Immunology等学术期刊撰写综述，为国际学术会议做大会报告，为Nature Cell Biology、Journal of Experimental Medicine、Nano Letters、Cell Research等期刊审稿。


授课情况


招生专业

遗传学，细胞生物学,生物化学，发育生物学，生物医学


代表性论文和论著

  1. Meng Y, Zhao Q, An L, Jiao S, Li R, Sang Y, Liao J, Nie P, Wen F, Ju J et al. A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells. Cancer Res 2021, 33619115.

  2. Tang Y, Fang G, Guo F, Zhang H, Chen X, An L, Chen M, Zhou L, Wang W, Ye T et al. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell 2020, 38(1): 115-128 e119.

  3. An L, Nie P, Chen M, Tang Y, Zhang, H, Guan J, Cao Z, Hou C, Wang W, Zhao Y et al. MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway. The Journal of experimental medicine 2020, 217(6): e20191817.

  4. Xu J, Tang Y, Sheng X, Tian Y, Deng M, Du S, Lv C, Li G, Pan Y, Song Y et al: Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling. The EMBO journal 2020, 39(7):e103255.

  5. Tang Y, Chen M, Zhou L, Ma J, Li Y, Zhang H, Shi Z, Xu Q, Zhang X, Gao Z et al: Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discov 2019, 5:3.

  6. Li Y, Guan J, Wang W, Hou C, Zhou L, Ma J, Cheng Y, Jiao S, Zhou Z: TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts. The Journal of biological chemistry 2019, 294(8):2744-2756.

  7. Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, Cheng Y, Zhou Z: Targeting IRF3 as a YAP agonist therapy against gastric cancer. The Journal of experimental medicine 2018, 215(2):699-718.

  8. Chen M, Zhang H, Shi Z, Li Y, Zhang X, Gao Z, Zhou L, Ma J, Xu Q, Guan J et al: The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. The Journal of biological chemistry 2018, 293(37):14455-14469.

  9. Shi Z, He F, Chen M, Hua L, Wang W, Jiao S, Zhou Z: DNA-binding mechanism of the Hippo pathway transcription factor TEAD4. Oncogene 2017, 36(30):4362-4369.

  10. Jiao S, Li C, Hao Q, Miao H, Zhang L, Li L, Zhou Z: VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nat Commun 2017, 8:14058.

  11. Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z: The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-kappaB Signaling via Partial Degradation of the NF-kappaB Subunit p100. The Journal of biological chemistry 2015, 290(32):19558-19568.

  12. Shi Z, Zhang Z, Zhang Z, Wang Y, Li C, Wang X, He F, Sun L, Jiao S, Shi W et al: Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling. The Journal of biological chemistry 2015, 290(44):26811-26820.

  13. Shi Z, Jiao S, Zhou Z: Structural dissection of Hippo signaling. Acta biochimica et biophysica Sinica 2015, 47(1):29-38.

  14. Jiao S, Zhang Z, Li C, Huang M, Shi Z, Wang Y, Song X, Liu H, Li C, Chen M et al: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. Nature immunology 2015, 16(3):246-257.

  15. Hao Q, Jiao S, Shi Z, Li C, Meng X, Zhang Z, Wang Y, Song X, Wang W, Zhang R et al: A non-canonical role of the p97 complex in RIG-I antiviral signaling. The EMBO journal 2015, 34(23):2903-2920.

  16. Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z et al: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell research 2014, 24(3):331-343.

  17. Liu G, Shi Z, Jiao S, Zhang Z, Wang W, Chen C, Hao Q, Zhang M, Feng M, Xu L et al: Structure of MST2 SARAH domain provides insights into its interaction with RAPL. Journal of structural biology 2014, 185(3):366-374.

  18. Li C, Feng M, Shi Z, Hao Q, Song X, Wang W, Zhao Y, Jiao S, Zhou Z: Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1. The Journal of biological chemistry 2014, 289(52):35969-35978.

  19. Jiao S, Wang H, Shi Z, Dong A, Zhang W, Song X, He F, Wang Y, Zhang Z, Wang W et al: A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer cell 2014, 25(2):166-180.

  20. Chen CC, Shi ZB, Zhang WQ, Chen M, He F, Zhang ZZ, Wang YC, Feng M, Wang WJ, Zhao Y et al: Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2: 2 Heterotetrameric Core of Striatin- interacting Phosphatase and Kinase ( STRIPAK) Complex*. Journal of Biological Chemistry 2014, 289(14):9651-9661.

  21. Zhang M, Dong L, Shi Z, Jiao S, Zhang Z, Zhang W, Liu G, Chen C, Feng M, Hao Q et al: Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure (London, England : 1993) 2013, 21(4):680-688.

  22. Shi Z, Jiao S, Zhang Z, Ma M, Zhang Z, Chen C, Wang K, Wang H, Wang W, Zhang L et al: Structure of the MST4 in complex with MO25 provides insights into its activation mechanism. Structure (London, England : 1993) 2013, 21(3):449-461.

  23. Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z: Structural insights into SUN-KASH complexes across the nuclear envelope. Cell research 2012, 22(10):1440-1452.

  24. Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z et al: Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell reports 2012, 1(6):665-675.