姓名：周兆才
职称：教授
E-mail: zhouzhaocai@fudan.edu.cn
办公地点：发育生物楼334室
研究方向
长期关注组织器官间通讯与疾病特别是胃与肠、肝、脑等器官之间的相互作用与重塑，从上皮、间质、免疫、神经等不同类型细胞相互协同的角度阐释胃肠组织稳态与疾病发生，从分子细胞信号机制的角度探索中枢及外周神经与胃癌发生发展的关系。近年来研究胃肠道肿瘤发生及免疫应答，代表性工作聚焦Hippo信号通路调控肿瘤发生及免疫应答的机制与功能，发现了一批疾病诊断标志物和先导药物，以通讯或共同通讯作者在Cancer Cell (2020/2014)、Nat Immunol (2015)、Nat Commun (2022/2017)、J Clin Invest (2022)、J Exp Med (2020/2018)、EMBO J (2020/2015) 、Cancer Res (2021)、Adv Sci (2021) 、Protein Cell (2023/2013)、Cell Res (2014/2012)、Cell Discov (2019)、Nano Lett (2021) 、Cell Rep (2012)等国际学术期刊发表研究论文80余篇，参与编写英文专著1部，申请发明专利10余项。成果被Cell、Nature、F1000Prime等评价和推荐，多次应邀为Oncogene、Cellular Molecular Immunology、FrontiersCellDevelopmentalBiology等撰写综述或组织主题专刊，为国际学术会议做大会报告，为Nature Cell Biology、Nature Chemical Biology、Journal of Clinical Investigation、Journal of Experimental Medicine、Cell Research、ProteinCell等国际学术期刊审稿。
个人简介
院长助理/国家杰青/科技部重点研发首席/中科院百人计划优秀
2004年博士毕业于中国科学技术大学，随后赴美国宾州大学（UPenn）从事博士后研究。2009年中国科学院“百人计划”引进回国，历任中科院上海生化与细胞所、分子生物学国家重点实验室、细胞生物学国家重点实验室研究员。2014年获中科院百人计划终期评估“优秀”，同年被授予中科院杰出青年科技创新人才称号。2017年任中科院分子细胞科学卓越创新中心特聘研究员，同年获国家自然科学基金委医学部“杰青”资助。2020年任mg4355电子娱乐官网特聘教授，遗传工程国家重点实验室研究组长。担任国家科技部 “发育和代谢：组织器官生长与尺寸控制” 重点专项首席科学家。主持国家自然科学基金委重点、重大、面上及上海市重点等基金项目，并获中科院战略性科技先导专项资助。曾任中科院与高校联合交叉创新团队负责人（GPCR信号转导）。担任Frontiers in Immunology等学术期刊编辑；《细胞生物学》、《生命的化学》等期刊编委；上海市生物工程学会理事、中国抗癌协会肿瘤胃肠病学专业委员会委员、中国细胞生物学会医学细胞生物学分会委员。
授课情况
癌生物学
招生专业
遗传学
科研项目
主持国家重点研发计划，国家自然科学基金等项目。
代表性论文
1. Meng Y, Ye F, Nie P, Zhao Q, An L, Wang W, Qu S, Shen Z, Cao Z, Zhang X, et al. Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells. J Hepatol. 2023. 79(6):1435-1449.
2. Jiao S, Li C, Guo F, Zhang J, Zhang H, Cao Z, Wang W, Bu W, Lin M, Lü J, et al. SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness. Nature Communications. 2023;14:6416.
3. Cao JJ, Ji LL, Zhan YX, Shao X, Xu PC, Wu BT, Chen P, Cheng LY, Zhuang XB, Ou Y, et al. MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages. Cellular & molecular immunology. 2023. 20(12):1413-1427.
4. Nie P, Zhang W, Meng Y, Lin M, Guo F, Zhang H, et al. A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer. Protein & cell. 2023, 14(7):513-31.
5. Guo Y, Zhu Z, Huang Z, Cui L, Yu W, Hong W, et al. CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis. Nat Commun. 2022, 13(1):4995.
6. Chen K, Tang Y, Wu M, Wan XC, Zhang YN, Chen XX, et al. Head-to-Tail Cross-Linking to Generate Bicyclic Helical Peptides with Enhanced Helicity and Proteolytic Stability. Org Lett. 2022, 24(1):53-7.
7. An L, Cao Z, Nie P, Zhang H, Tong Z, Chen F, et al. Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers. J Clin Invest. 2022, 132(9).
8. Zhou Z, Yuan Z, Hong W, Wang W. Editorial: A Hippo's View: From Molecular Basis to Translational Medicine. Front Cell Dev Biol. 2021, 9:729155.
9. Zhang H, Lin M, Dong C, Tang Y, An L, Ju J, et al. An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis. Adv Sci (Weinh). 2021, 8(17):e2004850.
10. Meng Y, Zhao Q, An L, Jiao S, Li R, Sang Y, et al. A TNFR2-hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells. Cancer Res. 2021, 81(11):3036-50.
11. Li G, Hu X, Nie P, Mang D, Jiao S, Zhang S, et al. Lipid-Raft-Targeted Molecular Self-Assembly Inactivates YAP to Treat Ovarian Cancer. Nano Lett. 2021, 21(1):747-55.
12. Chen XX, Tang Y, Wu M, Zhang YN, Chen K, Zhou Z, et al. Helix-Constrained Peptides Constructed by Head-to-Side Chain Cross-Linking Strategies. Org Lett. 2021, 23(20):7792-6.
13. An L, Nie P, Chen M, Tang Y, Zhang, H, Guan J, Cao Z, Hou C, Wang W, Zhao Y et al. MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway. The Journal of experimental medicine 2020, 217(6): e20191817.
14. Xu J, Tang Y, Sheng X, Tian Y, Deng M, Du S, Lv C, Li G, Pan Y, Song Y et al: Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling. The EMBO journal 2020, 39(7):e103255.
15. Tang Y, Chen M, Zhou L, Ma J, Li Y, Zhang H, Shi Z, Xu Q, Zhang X, Gao Z et al: Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discov 2019, 5:3.
16. Li Y, Guan J, Wang W, Hou C, Zhou L, Ma J, Cheng Y, Jiao S, Zhou Z: TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts. The Journal of biological chemistry 2019, 294(8):2744-2756.
17. Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, Cheng Y, Zhou Z: Targeting IRF3 as a YAP agonist therapy against gastric cancer. The Journal of experimental medicine 2018, 215(2):699-718.
18. Chen M, Zhang H, Shi Z, Li Y, Zhang X, Gao Z, Zhou L, Ma J, Xu Q, Guan J et al: The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. The Journal of biological chemistry 2018, 293(37):14455-14469.
19. Shi Z, He F, Chen M, Hua L, Wang W, Jiao S, Zhou Z: DNA-binding mechanism of the Hippo pathway transcription factor TEAD4. Oncogene 2017, 36(30):4362-4369.
20. Jiao S, Li C, Hao Q, Miao H, Zhang L, Li L, Zhou Z: VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nat Commun 2017, 8:14058.
21. Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z: The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-kappaB Signaling via Partial Degradation of the NF-kappaB Subunit p100. The Journal of biological chemistry 2015, 290(32):19558-19568.
22. Shi Z, Zhang Z, Zhang Z, Wang Y, Li C, Wang X, He F, Sun L, Jiao S, Shi W et al: Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling. The Journal of biological chemistry 2015, 290(44):26811-26820.
23. Shi Z, Jiao S, Zhou Z: Structural dissection of Hippo signaling. Acta biochimica et biophysica Sinica 2015, 47(1):29-38.
24. Jiao S, Zhang Z, Li C, Huang M, Shi Z, Wang Y, Song X, Liu H, Li C, Chen M et al: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. Nature immunology 2015, 16(3):246-257.
25. Hao Q, Jiao S, Shi Z, Li C, Meng X, Zhang Z, Wang Y, Song X, Wang W, Zhang R et al: A non-canonical role of the p97 complex in RIG-I antiviral signaling. The EMBO journal 2015, 34(23):2903-2920.
26. Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z et al: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell research 2014, 24(3):331-343.
27. Liu G, Shi Z, Jiao S, Zhang Z, Wang W, Chen C, Hao Q, Zhang M, Feng M, Xu L et al: Structure of MST2 SARAH domain provides insights into its interaction with RAPL. Journal of structural biology 2014, 185(3):366-374.
28. Li C, Feng M, Shi Z, Hao Q, Song X, Wang W, Zhao Y, Jiao S, Zhou Z: Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1. The Journal of biological chemistry 2014, 289(52):35969-35978.
29. Jiao S, Wang H, Shi Z, Dong A, Zhang W, Song X, He F, Wang Y, Zhang Z, Wang W et al: A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer cell 2014, 25(2):166-180.
30. Chen CC, Shi ZB, Zhang WQ, Chen M, He F, Zhang ZZ, Wang YC, Feng M, Wang WJ, Zhao Y et al: Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2: 2 Heterotetrameric Core of Striatin- interacting Phosphatase and Kinase ( STRIPAK) Complex*. Journal of Biological Chemistry 2014, 289(14):9651-9661.
31. Zhang M, Dong L, Shi Z, Jiao S, Zhang Z, Zhang W, Liu G, Chen C, Feng M, Hao Q et al: Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure (London, England : 1993) 2013, 21(4):680-688.
32. Shi Z, Jiao S, Zhang Z, Ma M, Zhang Z, Chen C, Wang K, Wang H, Wang W, Zhang L et al: Structure of the MST4 in complex with MO25 provides insights into its activation mechanism. Structure (London, England : 1993) 2013, 21(3):449-461.
33. Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z: Structural insights into SUN-KASH complexes across the nuclear envelope. Cell research 2012, 22(10):1440-1452.
34. Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z et al: Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell reports 2012, 1(6):665-675.