职称:青年研究员
办公地点:mg4355娱乐线路检测官网A301-6
办公电话:021-31246591
个人简介
女,博士,mg4355娱乐线路检测官网青年研究员。2008-2012、2012-2017年就读于中山大学环境科学与工程学院,分别获学士与博士学位。2017-2020年加入中山大学中山医学院吴忠道教授团队及中国疾病预防控制中心传染病预防控制所张永振教授团队从事博士后研究。2018年5月至今在mg4355电子娱乐官网附属上海市公共卫生临床中心兼任青年研究员,从事病毒学及新发传染病研究。2022年8月加入mg4355娱乐线路检测官网张永振教授团队,任青年研究员,致力于病毒发现、病毒遗传进化、病毒生态学,及病毒与宿主相互作用等研究。近年来以第一或通讯作者(含共同)在Nature、Cell、Nat Microbiol、EMBO J、BMC Med等国际著名期刊发表论文10余篇,并获Nature、Science、Nat Rev Microbiol、EMBO J等期刊配发评论文章对相关研究的科学意义予以高度评价。2021年入选上海市青年科技启明星计划。
研究方向
新病毒发现、病毒遗传进化与生态学、病毒与宿主间的相互作用、新发传染病等。
代表性论文 (#一作,*通讯)
Chen YM#, Hu SJ#, Lin XD#, Tian JH#, Lv JX, Wang MR, Luo XQ, Pei YY, Hu RX, Song ZG, Holmes EC, Zhang YZ*. 2023 Host traits shape virome composition and virus transmission in wild small mammals. Cell 186(21):4662-4675.e12.
Wu F#, Zhao S#, Yu B#, Chen YM#, Wang W#, Song ZG#, Hu Y#, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC and Zhang YZ*. 2020 A new coronavirus associated with human respiratory disease in China. Nature 579: 265-269.
Chen YM#, Sadiq S#, Tian JH, Chen X, Lin XD, Shen JJ, Chen H, Hao ZY, Wille M, Zhou ZC, Wu J, Li F, Wang HW, Yang WD, Xu QY, Wang W, Gao WH, Holmes EC, Zhang YZ*. 2022 RNA viromes from terrestrial sites across China expand environmental viral diversity. Nat Microbiol 7(8):1312-1323.
Chen YM#, Zheng YT#, Yu Y#, Wang YZ#, Huang XQ#, Qian F#, Sun L#, Song ZG, Chen ZY, Feng JW, An YP, Yang JC, Su ZQ, Sun SY, Dai FH, Chen QS, Lu QW, Li PC, Ling Y, Yang Z, Tang HR, Shi LM, Jin L, Holmes EC, Chen D, Zhu TY and Zhang YZ*. 2020 Blood molecular markers associated with COVID-19 Immunopathology and multiorgan damage. EMBO J 39: e105896.
Sun Z#, Song ZG#, Liu C#, Tan S#, Lin S, Zhu J, Dai FH, Gao J, She JL, Mei Z, Lou T, Zheng JJ, Liu Y, He J, Zheng Y, Ding C, Qian F, Zheng Y*, Chen YM*. 2022 Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients. BMC Med 20:24
Gao WH#, Lin XD#, Chen YM#, Xie CG, Tan ZZ, Zhou JJ, Chen S, Holmes EC and Zhang YZ*. 2020 Newly identified viral genomes in pangolins with fatal disease. Virus Evol 6: veaa020.
Song ZG#, Chen YM#, Wu F#, Xu L, Wang BF, Shi L, Chen X, Dai FH, She JL, Chen JM, Holmes EC, Zhu TY* and Zhang YZ*. 2020 Identifying the Risk of SARS-CoV-2 Infection and Environmental Monitoring in Airborne Infectious Isolation Rooms (AIIRs). Virol Sin35:785-792.
Chen YM, Holmes EC, Chen X, Tian JH, Lin XD, Qin XC, Gao WH, Liu J, Wu ZD* and Zhang YZ*. 2020 Diverse and abundant resistome in terrestrial and aquatic vertebrates revealed by transcriptional analysis. Sci Rep 10: 18870
Zhang YZ*, Chen YM, Wang W, Qin XC and Holmes EC. 2019 Expanding the RNA Virosphere by Unbiased Metagenomics. Annu Rev Virol 6: 119-139.
Wang W, Tian JH, Chen X, Hu RX, Lin XD, Pei YY, Lv JX, Zheng JJ, Dai FH, Song ZG, Chen YM, Zhang YZ*. 2022 Coronaviruses in wild animals sampled in and around Wuhan at the beginning of COVID-19 emergence. Virus Evol 8(1): veac046.
Shi M, Zhao S, Yu B, Wu WC, Hu Y, Tian JH, Yin W, Ni F, Hu HL, Geng S, Tan L, Peng Y, Song ZG, Wang W, Chen YM, Holmes EC, Zhang YZ*. 2022 Total infectome characterization of respiratory infections in pre-COVID-19 Wuhan, China. PLoS Pathog 18(2): e1010259.
Guo JJ# Lin XD#, Chen YM, Hao ZY, Wang ZX, Yu ZM, Lu M, Li K, Qin XC, Wang W, Holmes EC, Hou W* and Zhang YZ*. 2020 Diversity and circulation of Jingmen tick virus in ticks and mammals. Virus Evol6: veaa051.
Sadiq S, Chen YM, Zhang YZ, Holmes EC*. 2022 Resolving deep evolutionary relationships within the RNA virus phylum Lenarviricota. Virus Evol 8(1): veac055.