师基本信息
职称：研究员
电话：021-31246582
邮箱：bingzhao@fudan.edu.cn
地址：mg4355娱乐线路检测官网A501-4室
个人简介
男，1987年出生，博士、研究员、博士生导师。2005-2008年就读于中国农业大学生命科学试验班并获得学士学位；2008-2013年就读于清华大学mg4355娱乐线路检测官网并获得博士学位；2013-2015年于清华-北大生命科学联合中心进行博士后研究；2015-2017于美国辛辛那提儿童医院医学中心从事博士后研究；2017年起历任mg4355娱乐线路检测官网青年研究员、研究员；2019年起任mg4355电子娱乐官网附属中山医院双聘教授。
研究方向
利用小鼠遗传、类器官模型，研究成体干细胞命运决定机制，并发展类器官培育新策略。以第一/通讯作者身份于国际权威期刊Cell Research、Nature Communications、Advanced Science、Protein & Cell、Developmental Cell等发表系列性研究论文，为再生生物学发展提供重要基础。代表性研究成果获Nature News专访报道、Nature官网主页高亮，获国际权威综述期刊Nature Reviews Molecular Cell Biology、Nature Reviews Gastroenterology & Hepatology等高度评价。现作为首席科学家承担国家重点研发计划“干细胞及转化研究”重点专项（青年项目）。
获奖情况
复星医药奖教金（一等） （2020、2021）
国家优秀青年基金（2020）
“东方学者”特聘教授（2019）
上海市青年拔尖人才（2018）
上海市青年科技启明星（A类）（2018）
mg4355娱乐线路检测官网院长奖（2018）
AMGEN Postdoctoral Award（2015）
北京市优秀博士毕业生（2013）
代表性论文和论著
1. Liu G, Wei J, Li X, Tian M, Wang Z, Shen C, Sun W, Li C, Li X, Lv E, Tian S, Wang J*, Xu S* and Zhao B*. (2022) Near-infrared-responded high sensitivity nanoprobe for steady and visualized detection of albumin in hepatic organoids and mouse liver. Advanced Science (工程技术1区Top), doi.org/10.1002/advs.202202505. (* co-corresponding author)
2. Liang J, Qian J, Yang L, Chen X, Wang X, Lin X*, Wang X* and Zhao B*. (2022) Modeling human thyroid development by fetal tissue-derived organoid culture. Advanced Science (工程技术1区Top), doi.org/10.1002/advs.202105568.
3. Yang L, Chen J, Liang J, Zhang Y, Wang Q, Ren X, Wei J, Gong Q, Zhang J, Jiang N, Lin X, Li J* and Zhao B*. (2022) Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis. Protein & Cell (生物1区Top), doi.org/10.1007/s13238-021-00893-0.
4. Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B*, Jiang N*, Li R* and Lin X*. (2022) Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression. Developmental Cell (生物1区Top), 57:901–913. (Cover Story)
5. Huang M, Yang L, Jiang N, Dai Q, Li R, Zhou Z, Zhao B* and Lin X*. (2021) Emc3 maintains intestinal homeostasis by preserving secretory lineages. Mucosal Immunology (医学1区Top), 14:873-886. (Cover Story and 2021 Editor’ Choice)
6. Xiao H, Liang J, Liu S, Zhang Q, Xie F, Kong X, Guo S, Wang R, Fu R, Ye Z, Li Y, Zhang S, Zhang L, Kaudimba K, Wang R, Kong X, Zhao B*, Zheng X* and Liu T*. (2021) Proteomics and organoid culture reveal the underlying pathogenesis of Hashimoto’s thyroiditis. Frontiers in Immunology, 12:784975.
7. Sun S, Jiang N, Jiang Y, He Q, He H, Wang X, Yang L, Li R, Liu F, Lin X* and Zhao B*. (2020) Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers. Leukemia (医学1区Top), 34:3348-3358.
8. Zhao B*, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J*, Zhang R* and Lin X*. (2020) Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein & Cell (生物1区Top), 11(10):771-775. (Highlighted by Nature)
9. Wang X, Ni C, Jiang N, Wei J, Liang J, Zhao B* and Lin X*. (2020) Generation of liver bipotential organoids with a small-molecule cocktail. Journal of Molecular Cell Biology, 12(8): 618-629.
10. Zhao B*, Chen Ying, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G and Lin X*. (2019) Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation. Nature Communications (综合1区Top), 10:1071.
11. Wei J, Ran G, Wang X, Jiang N, Liang J, Lin X*, Ling C* and Zhao B*. (2019) Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors. Journal of Biological Chemistry, 294(38):14096-14104.
12. Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han JJ and Chen YG. (2017) BMP restricts intestinal Lgr5+ stem cell self-renewal by directly suppressing its signature genes. Nature Communications (综合1区Top), 8:13824.
13. Zhao B, Qi Z, Li Y, Wang C, Fu W and Chen YG*. (2015) The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells. Nature Communications (综合1区Top), 6:7166.
14. Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA and Chen X. (2015) Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. Nature Nanotechnology (工程技术1区Top), 10(5):465-71.
15. Cui HK#, Zhao B#, Li Y, Guo Y, Hu H, Liu L* and Chen YG*. (2013) Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling. Cell Research (生物1区Top), 23:581-584. (# co-first author)
16. Zhao B, Wang Q, Du J, Luo S, Xia J and Chen YG*. (2012) PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor. Cell Research (生物1区Top), 22:1467-1478.